Molecular clocks are the basis for dating the divergence between lineages over macroevolutionary timescales (~105to 108years). However, classical DNA-based clocks tick too slowly to inform us about the recent past. Here, we demonstrate that stochastic DNA methylation changes at a subset of cytosines in plant genomes display a clocklike behavior. This “epimutation clock” is orders of magnitude faster than DNA-based clocks and enables phylogenetic explorations on a scale of years to centuries. We show experimentally that epimutation clocks recapitulate known topologies and branching times of intraspecies phylogenetic trees in the self-fertilizing plant
Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher.
Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?
Some links on this page may take you to non-federal websites. Their policies may differ from this site.
-
Arabidopsis thaliana and the clonal seagrassZostera marina , which represent two major modes of plant reproduction. This discovery will open new possibilities for high-resolution temporal studies of plant biodiversity.Free, publicly-accessible full text available September 29, 2024 -
Free, publicly-accessible full text available December 1, 2024
-
Free, publicly-accessible full text available November 1, 2024
-
Free, publicly-accessible full text available November 1, 2024
-
Abstract A description is presented of the algorithms used to reconstruct energy deposited in the CMS hadron calorimeter during Run 2 (2015–2018) of the LHC. During Run 2, the characteristic bunch-crossing spacing for proton-proton collisions was 25 ns, which resulted in overlapping signals from adjacent crossings. The energy corresponding to a particular bunch crossing of interest is estimated using the known pulse shapes of energy depositions in the calorimeter, which are measured as functions of both energy and time. A variety of algorithms were developed to mitigate the effects of adjacent bunch crossings on local energy reconstruction in the hadron calorimeter in Run 2, and their performance is compared.
Free, publicly-accessible full text available November 1, 2024 -
Free, publicly-accessible full text available November 1, 2024
-
Abstract A search for decays to invisible particles of Higgs bosons produced in association with a top-antitop quark pair or a vector boson, which both decay to a fully hadronic final state, has been performed using proton-proton collision data collected at
by the CMS experiment at the LHC, corresponding to an integrated luminosity of 138$${\sqrt{s}=13\,\text {Te}\hspace{-.08em}\text {V}}$$ . The 95% confidence level upper limit set on the branching fraction of the 125$$\,\text {fb}^{-1}$$ Higgs boson to invisible particles,$$\,\text {Ge}\hspace{-.08em}\text {V}$$ , is 0.54 (0.39 expected), assuming standard model production cross sections. The results of this analysis are combined with previous$${\mathcal {B}({\textrm{H}} \rightarrow \text {inv})}$$ searches carried out at$${\mathcal {B}({\textrm{H}} \rightarrow \text {inv})}$$ , 8, and 13$${\sqrt{s}=7}$$ in complementary production modes. The combined upper limit at 95% confidence level on$$\,\text {Te}\hspace{-.08em}\text {V}$$ is 0.15 (0.08 expected).$${\mathcal {B}({\textrm{H}} \rightarrow \text {inv})}$$ Free, publicly-accessible full text available October 1, 2024 -
Free, publicly-accessible full text available October 1, 2024